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Capomixol – infusion solution

INSTRUCTIONS FOR MEDICAL USE

CAPOMIXOL

Trade name of the drug: Capomixol.

Pharmaceutical form: Solution for infusion.

Contents:

100 ml of the solution contains:

Active ingredients: sodium chloride – 175 mg, potassium chloride – 150 mg, sodium lactate – 224 mg, glucose – 2700 mg; Excipients: water for injection.

Description: colorless or almost colorless transparent solution.

Pharmacotherapeutic group: Saline solutions

ATX code: B05CB

Pharmacological properties

Pharmacodynamics

A complex preparation of ionic composition.

Sodium is the main extracellular cation. The concentration of extracellular fluid depends on it: 92% of cations and almost half of all extracellular osmotically active particles. It is considered the major element for the maintenance of hemostasis with chlorine anion.

Calcium is involved in muscle contraction, impulse transmission through nerve tissues, and blood clotting. Leads to a decrease in the conductivity of the walls of blood vessels, and prevents the development of inflammatory edema.

Potassium is the main intracellular cation. Plays a major role in the process of excitation of neuronal and muscle cells. Participates in the metabolism of proteins and carbohydrates. Lactic acid anions (lactate) attaches hydrogen ions, thus preventing acidosis. Its action is slower than that of bicarbonate and does not cause abrupt changes in pH.

Glucose is considered to be the most important and convenient source of energy for metabolic processes.

So, the drug helps to normalize the volume of circulating blood in the body, improve microcirculation, prevent acidosis, reduce intoxication.

Pharmacokinetics

After introduction into the bloodstream sodium lactate reacts with carbonate anhydride and water to form sodium bicarbonate, only half (L isomer) of the sodium lactate, which leads to an increase in the alkaline blood reserve, is considered active, while the rest (D isomer) is not metabolized and is excreted with urine.

Sodium chloride is rapidly excreted from the body and temporarily increases circulating blood volume. It increases diuresis.

Glucose molecules are spent in the process of providing energy to the body. After entering the tissues, glucose is phosphorylated and converted into glucose-6-phosphate, and then enters the metabolism (the last metabolic products are carbon dioxide and water). Easily penetrates through histohematic barriers to all organs and tissues. Fully absorbed by the body, it is not excreted by the kidneys (occurrence in the urine is a pathological indicator).

Indications for use

Shock, thermal trauma, acute blood loss; hypohydration (isotonic and hypotonic forms); metabolic acidosis; acute peritonitis, intestinal obstruction (for correction of water and salt balance); decompensation of electrolyte disturbances in patients with intestinal fistulas; therapeutic plasmapheresis (dialysis-filtration method).

Administration and dosages

Administered as an intravenous infusion. Dosage depends on patient’s age, body weight and clinical condition. The following dosages are generally used.

The daily dose for adults is 5-20 ml/kg; if necessary, it can be increased to 30-40 ml/kg. The drug is administered at the rate of 60-80 drops/min, trickle administration is allowed.

For children the daily dose is 5-10 ml/kg and the infusion rate is 30-60 drops/minute.

Side effects

Anaphylactoid reactions (tachycardia, decreased BP, itching, skin hyperemia, dyspnea, hyperthermia), hyperkalemia. Allergic reactions.

Contraindications

Hypersensitivity, alkalosis, extracellular hyperhydration, hypertensive dehydration, hypernatriemia, conditions in which the administration of large volumes of fluid is contraindicated: severe CHF, cerebral edema, pulmonary edema, anuria.

Drug interactions

Increased retention of Na+ in the body is possible with concomitant administration of NSAIDs, androgens, estrogens, anabolic hormones, corticotropin, mineralocorticoids, vasodilators or ganglioblocators.

Special indications

In the treatment of severe hypovolemia, simultaneous therapy with colloidal solutions, blood and its components is recommended (due to the short-lived action of the drug). During long-term administration of large doses of the solution, it is advisable to monitor the electrolytes in the plasma and urine.

Use during pregnancy and lactation:

There are no data concerning contraindications during pregnancy and lactation.

Overdose

Symptoms: papilledema of the optic nerve, cerebral edema, seizures, hyperthermia. A toxic dose of sodium chloride is 100-150 g.

Form of production

Package: 100 ml, 200 ml or 250 ml in vials.

Storage conditions

Store in a dry, dark place at temperatures not exceeding 25oC. Do not freeze. Keep out of the reach of children!

Shelf life

2 years. Do not use after the expiration date.

Conditions of dispensing from pharmacies

Released by a doctor’s prescription.

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