INSTRUCTIONS FOR MEDICAL USE
LIGNOVA
Trade name of the drug: Lignova
Active substance (INN): hydrolysis lignin
Dosage form: powder for preparation of oral solution.
Contents: hydrolyzed lignin
Description: dark brown to black amorphous powder without odor.
Pharmacotherapeutic group: medicine for detoxification of the body.
ATX code: A07BC
Pharmacological properties
Pharmacodynamics
The drug is a natural enterosorbent consisting of products of hydrolysis of cotton fiber components – lignin polymer, whose structural elements are derivatives of phenylpropane and hydrocellulose.
It has high sorption activity and non-specific detoxifying effect.
It binds and removes from the body pathogenic bacteria and their endotoxins, drugs, poisons, salts of heavy metals, alcohol, allergens, as well as excess of certain metabolic products, including bilirubin, cholesterol, urea, metabolites responsible for the development of endogenous toxicity.
Non-toxic, not absorbed, completely eliminated from the intestine within 24 hours.
Indications for use
As a detoxifying agent in adults and children in exogenous and endogenous intoxications of various origins:
- Drug poisoning, alkaloids, salts of heavy metals, alcohol and other harmful substances;
- complex treatment of food poisoning, such as salmonellosis, dysentery, dyspepsia;
- purulent inflammatory diseases that are clearly indicative of poisoning;
- Hyperbilirubinemia and hyperazotemia associated with hepatic and renal failure;
- food and drug allergies;
- For the prevention of chronic diseases in personnel working in hazardous conditions.
Dosage and administration
The drug is taken orally an hour before a meal and taking medications, stirring 5 grams in 100 ml of boiled and cooled water.
The daily dose depends on the severity of the disease, body weight and age of the patient and is 0.5-1.0 g / kg body weight in 2-4 times a day. Average single doses: for children aged 7-14 years old – 5 g 2-4 times daily; for children over 14 years old and adults – 5-10 g 3-4 times daily. Duration of intake in acute conditions of 3-5 days, with allergic diseases and chronic intoxications – up to 14 days. Repeated courses are carried out after 2 weeks on the doctor’s recommendation.
Possible gastric lavage of patients with acute poisoning with a probe using the drug.
Side effects
The drug is well tolerated. Use of the drug may cause stool coloring in black, which is not a contraindication for the drug use. Allergic reactions and constipation are rare. Prolonged use may lead to impaired absorption of vitamins, calcium, in connection with which preventive administration of multivitamins and calcium preparations is recommended.
Contraindications
Individual intolerance to the drug. It is not advisable to use the drug in acute gastric and 12 duodenal ulcer, bowel atony.
Drug interactions
Because of the adsorptive properties, the drug is able to reduce the effectiveness of simultaneously taken drugs, so it is not recommended to take other drugs 2 hours before and 2 hours after taking the drug.
Special indications
Not described.
Overdose
It has not been described.
Form of production
Powder for preparation of solution for oral administration 5 g №10 (1х10), №20 (2х10), №30 (3х10) in sachets or 10 g, 35 g, 50 g, 70 g, 105 g, 200 g in vials.
Storage conditions
Store in a dry, dark place at temperatures under 25 ° C. Keep out of the reach of children!
Shelf life
2 years. Do not use after the expiration date.
Conditions for dispensing from pharmacies
Released without a prescription.