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Remetic ®- suspension

INSTRUCTIONS FOR MEDICAL USE

REMETIC®

Trade name of the drug: Remetik®

Active ingredients (INN): Aluminum hydroxide, magnesium hydroxide, simethicone.

Dosage form: suspension

Composition:

5 ml of suspension contain:

Active ingredients: dried aluminum hydroxide gel (equivalent to aluminum hydroxide) – 405 mg, magnesium hydroxide – 100 mg, simethicone – 125 mg.

Excipients: sorbitol 70%, mannitol, hydrogen peroxide, methyl paraben, propyl paraben, citric acid, sodium saccharin, ethanol 95%, peppermint oil, guar gum, purified water.

Description: white or almost white suspension with characteristic odor of peppermint. Pharmacotherapeutic group: Antacid

ATX code: A02AX

Pharmacological properties

The drug is a well-balanced combination of active substances. Aluminum hydroxide neutralizes excess of hydrochloric acid in the stomach, forming aluminum chloride. Aluminum chloride is converted by hydrochloric acid to alkaline aluminum salts, which are very poorly resorbed but are excreted through the gastrointestinal tract. The content of aluminum ions in blood serum is almost unchanged.

Magnesium hydroxide also neutralizes hydrochloric acid in the stomach by converting into magnesium chloride. In the intestine this salt forms poorly resorbable magnesium carbonate and does not significantly change the concentration of magnesium ions in the blood.

In patients with chronic renal insufficiency serum levels of magnesium and aluminum ions may increase to toxic values as a result of their impaired excretion.

Simethicone acts throughout the gastrointestinal tract and is an inert compound. It has a carminative effect (eliminates flatulence). It reduces the surface tension at the interface, which hinders the formation of gas bubbles and promotes their destruction in the mucus and suspension of the gastrointestinal tract contents.

Simethicone when used with antacids enhances their coating effect and thus protects the mucous membrane from the effects of aggressive factors. It does not affect absorption of other substances, it cumulates and does not contribute to cumulation, does not change pH and chemical environment of the gastrointestinal tract and is excreted unchanged. The drug generally helps to provide high neutralizing ability against free hydrochloric acid and protective properties against the mucous membrane of the gastrointestinal tract. It has antacidic, debulking and adsorptive effects. By neutralizing hydrochloric acid reduces acidity, keeps it at a constant level.

Indications for use

  • Peptic ulcer in the acute phase (in combination therapy);
  • Acute gastritis, chronic gastritis in the acute phase;
  • esophageal hernia of the diaphragm;
  • duodenitis;
  • reflux esophagitis;
  • discomfort, flatulence, pain in the epigastrium, heartburn, acid reflux arising from improper diet, excessive consumption of alcohol, coffee and nicotine.

Dosage and administration

Suspension for oral administration. Shake the bottle with the suspension well before use.

Adults should take 2 tea spoons (10 ml) 4 times per day 30-40 times before meals (if not stated otherwise by the doctor). If you have reflux esophagitis, also take 2 tea spoon (10 ml) 1 hour after the meal. If it is used occasionally (discomfort due to wrong eating), 2 teaspoons (10 ml) once. The maximum daily dose is 16 teaspoons (80 ml). For children over 10 years old – 1 teaspoon (5 ml) 2 times a day, an hour after meals (if not stated otherwise by the doctor).

Side effects

Gastrointestinal tract: in rare cases, when taking high doses, nausea, vomiting, diarrhea or constipation, changes in taste.

Metabolism disorders: in patients with renal insufficiency in high doses osteomalacia may occur due to impaired excretion of aluminum by kidneys and its deposition in bones; with long-term use hypophosphatemia may develop, which in more severe form can lead to anorexia, muscle weakness and osteomalacia.

Other: arthralgia, exacerbation of Alzheimer’s disease (in elderly people).

Contraindications

  • Hypersensitivity to the drug components;
  • Severe renal dysfunction;
  • Children under 10 years of age;
  • Pregnancy and lactation.

Drug interactions

The drug may decrease the therapeutic effect if simultaneously taken with the following drugs: tetracycline-type antibiotics, vitamins, digoxin, histamine H2-receptor blockers, iron salts, ciprofloxacin, phenothiazine, isoniazid, beta-adrenoblockers, indomethacin and ketoconozole.

Special indications

The drug should be used with caution in patients with liver diseases and central nervous system, patients with alcoholism and epilepsy. When using the drug together with other drugs, the interval between doses must be at least 2 hours.

If necessary, the drug is prescribed to patients with impaired renal function or liver function and elderly patients with special caution and under supervision of the attending physician.

It is recommended to monitor blood levels of phosphorus and magnesium during long-term use of the drug. The drug does not cause changes in psychophysical state of a patient and does not affect his ability to drive vehicles and operate machinery.

Overdose

Symptoms: Signs of impaired metabolism of calcium, magnesium, phosphorus (weakness, bone pain, redness of the skin, inadequate behavior).

Treatment: if necessary symptomatic therapy is carried out.

Form of production

Suspension in 90 ml, 100 ml, 150 ml, 200 ml bottles, including measuring spoon or cup.

Conditions of storage

Store in a dry place, protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children!

Shelf life

3 years. Do not use after the expiration date.

Conditions of dispensing from pharmacies

Released without a prescription.

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